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HARP prevention 2
HARP prevention 2 is lead by Principal Investigator Dr Murali Shyamsundar at Queen’s University Belfast. It started on 1st April 2016 and is funded by NIHR Clinician Scientist Award.
About the study
Acute respiratory distress syndrome (ARDS) is a serious illness which affects the lungs and can occur after surgery such as removal of the food pipe (oesophagectomy).
The objective of this trial is to investigate the efficacy of simvastatin in reducing the occurrence of ARDS and other post-operative complications in patients undergoing oesophagectomy. If effective, there will be significant benefits to patients and the NHS.
This project will deliver a multi-centre, randomized, double blind placebo controlled clinical trial to determine whether in patients undergoing elective oesophagectomy, simvastatin 80mg or placebo for four days pre-surgery and up to 7 days post-surgery improves patient outcomes. It will recruit 452 patients from at least 12 sites.